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KMID : 0525619980030040286
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1998 Volume.3 No. 4 p.286 ~ p.302
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Structural Importance of β-1,4-N-Acetylglucosamine Backbone in Human Biseases Including Malignant Cancer and Inflammation
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김세권/Kim SK
Kim CH
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Abstract
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Recent evidence demonstrates that the changes in the size of N-linked oligosacchardes that correlate with cell transformation and tumorigenicity are due to at least in part to the regulation of expression of a glycosyltransferase involved in the branching of N-linked structures, N-acetylglucosaminyltransferase V or GlcNAcT-V. Studies have shown that the increases in GlcNAcT-V expression after oncogenic transformation are most likely caused by direct effects on the GlcNAcT-V promoter by the Rts family of transcriptional activators, which are up-regulated by a cellular proliferation signaling pathway. This pathway begins with growth factor receptors that activate tyrosine kinases at the cell surface and proceeds through src, ras and raf. Biological mechanism for the association between cellular proliferation and GlcNAcT-V expression will be discussed, as well as a discussion of the effects of b(1,6) branching on several of the phentypes of oncogenically transformed cells, including metastatic potential. From these background of N-acetylglucosamine-based transferases, it would be probably postulated that the N-acetylglucosamine and deacetylated poymers of chitin and chitosan could be regarded as these transferase inhibitors and applicable in cancer metastasis and human diseases.
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KEYWORD
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